News:

Job offers at the moment: 

PhD Student Position at Orthopedic Department, University Hospital Ulm (until November 6th, 2020)

Two Postdoctoral research positions available "Roles of Radiotherapy on Tumor Microenvironment"


Publications:

 

Abety AN, Pach E, Giebeler N, Fromme JE, Aramadhaka LR, Mauch C, Fox JW, Zigrino P. Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth. Biomolecules. 2020 Sep 7;10(9):E1290. doi: 10.3390/biom10091290.

 

Adamo CS, Zuk AV, Sengle G. The fibrillin microfibril/ elastic fiber network: A critical extracellular supramolecular: scaffold to balance skin homeostasis.  Exp Dermatol. 2020 Sep 13. doi: 10.1111/exd.14191. Online ahead of print.

 

Berberich B, Thriene K, Gretzmeier C, Kühl T, Bayer H, Athanasiou I, Rafei-Shamsabadi DA, Bruckner-Tuderman L, Nyström A, Kiritsi D, Dengjel J. Proteomic Profiling of Fibroblasts Isolated from Chronic Wounds Identifies Disease-Relevant Signaling Pathways.  J Invest Dermatol. 2020 Apr 17:S0022-202X(20)31376-2. doi: 10.1016/j.jid.2020.02.040.

Bornert O, Hogervorst M, Nauroy P, Bischof J, Swildens J, Athanasiou I, Tufa SF, Keene DR, Kiritsi D, Hainzl S, Murauer EM, Marinkovich MP, Platenburg G, Hausser I, Wally V, Ritsema T, Koller U, Haisma EM, Nyström A. QR-313, an antisense oligonucleotide, shows therapeutic efficacy for treatment of dominant and recessive dystrophic epidermolysis bullosa: a preclinical study.
J Invest Dermatol. 2020 Sep 15:S0022-202X(20)32061-3. doi: 10.1016/j.jid.2020.08.018.

 

Brod F, Fässler R. A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane.  EMBO J. 2020 Aug 31:e106234. doi: 10.15252/embj.2020106234

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Börschel CS, Stejskalova A, Schäfer SD, Kiesel L, Götte M. miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function. Biomedicines. 2020 Aug 18;8(8):291. doi: 10.3390/biomedicines8080291.

 

Dengjel J, Bruckner-Tuderman L, Nyström A. Skin proteomics - analysis of the extracellular matrix in health and disease.  Expert Rev Proteomics. 2020 May;17(5):377-391. doi: 10.1080/14789450.2020.1773261.

Espinoza-Sánchez NA, Götte M. Semin Role of cell surface proteoglycans in cancer immunotherapy. Cancer Biol. 2020 May;62:48-67. doi: 10.1016/j.semcancer.2019.07.012. Epub 2019 Jul 20.

 

Etich J, Rehberg M, Eckes B, Sengle G, Semler O, Zaucke F. Signaling pathways affected by mutations causing osteogenesis imperfecta. Cell Signal. 2020 Sep 24:109789. doi: 10.1016/j.cellsig.2020.109789. Online ahead of print.

 

Etich J, Leßmeier L, Rehberg M, Sill H, Zaucke F, Netzer C, Semler O. Osteogenesis imperfecta-pathophysiology and therapeutic options. Mol Cell Pediatr. 2020 Aug 14;7(1):9. doi: 10.1186/s40348-020-00101-9.

 

Fahim SA, Abdullah MS, Espinoza-Sánchez NA, Hassan H, Ibrahim AM, Ahmed SH, Shakir G, Badawy MA, Zakhary NI, Greve B, El-Shinawi M, Götte M, Ibrahim SA. Inflammatory Breast Carcinoma: Elevated microRNA miR-181b-5p and Reduced miR-200b-3p, miR-200c-3p, and miR-203a-3p Expression as Potential Biomarkers with Diagnostic Value.  Biomolecules. 2020 Jul 16;10(7):1059. doi: 10.3390/biom10071059.

 

Georgieva VS, Etich J, Bluhm B, Zhu M, Frie C, Wilson R, Zaucke F, Bateman J, Brachvogel B. Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage.  Int J Mol Sci. 2020 Jun 9;21(11):4112. doi: 10.3390/ijms21114112.

 

Gerarduzzi C, Hartmann U, Leask A, Drobetsky E. The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment.  Cancer Res. 2020 Jul 1;80(13):2705-2717. doi: 10.1158/0008-5472.CAN-18-2098. Epub 2020 Mar 19.

 

Grässel S, Muschter D. Recent advances in the treatment of osteoarthritis.  F1000Res. 2020 May 4;9:F1000 Faculty Rev-325. doi: 10.12688/f1000research.22115.1. eCollection 2020.

 

Grobe K, Guerrero I. Dally-like Is Unlike Dally in Assisting Wingless Spread.  Dev Cell. 2020 Sep 14;54(5):572-573. doi: 10.1016/j.devcel.2020.08.011.

 

Hallmann R, Hannocks MJ, Song J, Zhang X, Di Russo J, Luik AL, Burmeister M, Gerwien H, Sorokin L. Int The role of basement membrane laminins in vascular function. J Biochem Cell Biol. 2020 Oct;127:105823. doi: 10.1016/j.biocel.2020.105823.

 

Hedderich J, El Bagdadi K, Angele P, Grässel S, Meurer A, Straub RH, Zaucke F, Jenei-Lanzl Z. Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation.  Int J Mol Sci. 2020 May 30;21(11):3924. doi: 10.3390/ijms21113924.

 

Hendrickx G, Danyukova T, Baranowsky A, Rolvien T, Angermann A, Schweizer M, Keller J, Schröder J, Meyer-Schwesinger C, Muschol N, Paganini C, Rossi A, Amling M, Pohl S, Schinke T. Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes. Hum Mol Genet. 2020 Mar 27;29(5):803-816. doi: 10.1093/hmg/ddaa006.

 

Kleiser S, Nyström A. Interplay between Cell-Surface Receptors and Extracellular Matrix in Skin.  Biomolecules. 2020 Aug 11;10(8):1170. doi: 10.3390/biom10081170.

 

Köhler A, Mörgelin M, Gebauer JM, Öcal S, Imhof T, Koch M, Nagata K, Paulsson M, Zaucke F, Baumann U, Sengle G. New specific HSP47 functions in collagen subfamily chaperoning.  FASEB J. 2020 Jul 27. doi: 10.1096/fj.202000570R.

 

Kouwenberg M, Rops A, Bakker-van Bebber M, Diepeveen L, Götte M, Hilbrands L, van der Vlag J. Role of syndecan-1 in the interaction between dendritic cells and T cells. PLoS One. 2020 Jul 23;15(7):e0230835. doi: 10.1371/journal.pone.0230835. eCollection 2020.

 

Kumar Katakam S, Tria V, Sim WC, Yip GW, Molgora S, Karnavas T, Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Götte M. The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis.  FEBS J. 2020 May 5. doi: 10.1111/febs.15356

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Katakam SK, Pelucchi P, Cocola C, Reinbold R, Vlodavsky I, Greve B, Götte M Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells.. Front Oncol. 2020 May 14;10:774. doi: 10.3389/fonc.2020.00774.

 

Lewejohann L, Pallerla SR, Schreiber RS, Gerula J, Grobe K. Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function. J Dev Biol. 2020 Jul 11;8(3):E13. doi: 10.3390/jdb8030013

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Mohamed HT, Untereiner V, Cinque G, Ibrahim SA, Götte M, Nguyen NQ, Rivet R, Sockalingum GD, Brézillon S. Infrared Microspectroscopy and Imaging Analysis of Inflammatory and Non-Inflammatory Breast Cancer Cells and Their GAG Secretome.  Molecules. 2020 Sep 19;25(18):E4300. doi: 10.3390/molecules25184300.

Niedermair T, Schirner S, Lasheras MG, Straub RH, Grässel S. Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way. Mech Ageing Dev. 2020 Jul;189:111265. doi: 10.1016/j.mad.2020.111265. Epub 2020 May 22.

 

Nyström A, Kiritsi D. Transmembrane collagens - Unexplored mediators of epidermal-dermal communication and tissue homeostasis.  Exp Dermatol. 2020 Aug 31. doi: 10.1111/exd.14180.

 

Ponandai-Srinivasan S, Saare M, Boggavarapu NR, Frisendahl C, Ehrström S, Riethmüller C, García-Uribe PA, Rettkowski J, Iyengar A, Salumets A, Lalitkumar PGL, Götte M, Gemzell-Danielsson K. Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. Hum Reprod. 2020 Oct 1;35(10):2280-2293. doi: 10.1093/humrep/deaa164.

Rehberg M, Azim M, Martakis K, Winzenrieth R, Hoyer-Kuhn H, Schoenau E, Semler O, Duran I. Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy. J Bone Miner Res. 2020 Sep;35(9):1685-1694. doi: 10.1002/jbmr.4047. Epub 2020 Jun 1.

 

Rezaei M, Martins Cavaco AC, Stehling M, Nottebaum A, Brockhaus K, Caliandro MF, Schelhaas S, Schmalbein F, Vestweber D, Eble JA. Extracellular Vesicle Transfer from Endothelial Cells Drives VE-Cadherin Expression in Breast Cancer Cells, Thereby Causing Heterotypic Cell Contacts. Cancers (Basel). 2020 Aug 1;12(8):2138. doi: 10.3390/cancers12082138.

 

Sachs W, Sachs M, Krüger E, Zielinski S, Kretz O, Huber TB, Baranowsky A, Westermann LM, Voltolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C. Distinct Modes of Balancing Glomerular Cell Proteostasis in Mucolipidosis Type II and III Prevent Proteinuria. J Am Soc Nephrol. 2020 Aug;31(8):1796-1814. doi: 10.1681/ASN.2019090960. Epub 2020 Jul 8.

 

Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T. Role of collagen XII in skin homeostasis and repair.  Matrix Biol. 2020 Sep 2:S0945-053X(20)30087-1. doi: 10.1016/j.matbio.2020.08.002.

 

Solomon-Degefa H, Gebauer JM, Jeffries CM, Freiburg CD, Meckelburg P, Bird LE, Baumann U, Svergun DI, Owens RJ, Werner JM, Behrmann E, Paulsson M, Wagener R. Structure of a collagen VI α3 chain VWA domain array: adaptability and functional implications of myopathy causing mutations.  J Biol Chem. 2020 Sep 4;295(36):12755-12771. doi: 10.1074/jbc.RA120.014865.

 

Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.  Nat Commun. 2020 Jul 16;11(1):3559. doi: 10.1038/s41467-020-17358-3.

 

Teixeira FCOB, Götte M. Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation. Adv Exp Med Biol. 2020;1221:97-135. doi: 10.1007/978-3-030-34521-1_4.

 

Vijaya Kumar A, Brézillon S, Untereiner V, Sockalingum GD, Kumar Katakam S, Mohamed HT, Kemper B, Greve B, Mohr B, Ibrahim SA, Goycoolea FM, Kiesel L, Pavão MSG, Motta JM, Götte M. HS2ST1-dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior. Cancer Sci. 2020 Jun 23;111(8):2907-22. doi: 10.1111/cas.14539.

 

Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases.  J Histochem Cytochem. 2020 Jul 6:22155420930303. doi: 10.1369/0022155420930303. Online ahead of print.

 

Zhang X, Wang Y, Song J, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain.  J Exp Med. 2020 Jul 6;217(7):e20191339. doi: 10.1084/jem.20191339.

 

 

 


Obituaries