2023
Sigle M, Rohlfing AK, Kenny M, Scheuermann S, Sun N, Graeßner U, Haug V, Sudmann J, Seitz CM, Heinzmann D, Schenke-Layland K, Maguire PB, Walch A, Marzi J, Gawaz MP.
Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution.
19 Sep 2023, https://doi.org/10.1038/s41467-023-41417-0
Prag HA, Murphy MP, Krieg T.
Sox-2 positive cells identified in lymph nodes from endometriosis patients may play a role in the disease pathogenesis.
1 Sep 2023, https://doi.org/10.1016/j.ejogrb.2023.07.017
Anderle N, Schäfer-Ruoff F, Staebler A, Kersten N, Koch A, Önder C, Keller AL, Liebscher S, Hartkopf A, Hahn M, Templin M, Brucker SY, Schenke-Layland K, Schmees C.
Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment.
18 Aug 2023, https://doi.org/10.1186/s13046-023-02782-2
Rösch G, Zaucke F, Jenei-Lanzl Z.
Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis.
1 Aug 2023, https://doi.org/10.1152/ajpcell.00039.2023
Ewald CY, Nyström A.
Mechanotransduction through hemidesmosomes during aging and longevity.
1 Aug 2023, https://doi.org/10.1242/jcs.260987
Hsu CP, Aretz J, Hordeichyk A, Fässler R, Bausch AR.
Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes.
1 Aug 2023, https://doi.org/10.1073/pnas.2301881120
Luik AL, Hannocks MJ, Loismann S, Kapupara K, Cerina M, van der Stoel M, Tsytsyura Y, Glyvuk N, Nordenvall C, Klingauf J, Huveneers S, Meuth S, Jakobsson L, Sorokin L.
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication.
1 Aug 2023, https://doi.org/10.1016/j.matbio.2023.06.001
Brenneis M, Junker M, Sohn R, Braun S, Ehnert M, Zaucke F, Jenei-Lanzl Z, Meurer A.
Patellar malalignment correlates with increased pain and increased synovial stress hormone levels-A cross-sectional study.
27 Jul 2023, https://doi.org/10.1371/journal.pone.0289298
Injarabian L, Willenborg S, Welcker D, Sanin DE, Pasparakis M, Kashkar H, Eming SA.
FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue.
27 Jul 2023, https://doi.org/10.1016/j.jid.2023.06.203
Sawant M, Wang F, Koester J, Niehoff A, Nava MM, Lundgren-Akerlund E, Gullberg D, Leitinger B, Wickström S, Eckes B, Krieg T.
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis.
21 Jul 2023, https://pubmed.ncbi.nlm.nih.gov/37479494/
Burmeister M, Fraunenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, Kuhlmann T, Gross CC, Naik VN, Wiendl H, Klingauf J, Meissner F, Sorokin L.
Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function.
21 Jul 2023, https://doi.org/10.1126/sciadv.adg0686
Lau C, Muthu ML, Siddiqui IF, Li L, Reinhardt DP.
High fat diet has a protective sex-dependent effect on aortic aneurysm severity in a Marfan syndrome mouse model.
21 Jul 2023, https://doi.org/10.1016/j.cjca.2023.07.020
Rafaeva M, Jensen ARD, Horton ER, Zornhagen KW, Strøbech JE, Fleischhauer L, Mayorca-Guiliani AE, Nielsen SR, Grønseth DS, Kuś F, Schoof EM, Arnes L, Koch M, Clausen-Schaumann H, Izzi V, Reuten R, Erler JT.
Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression.
18 Jul 2023, https://doi.org/10.3389/fimmu.2023.1154528
Paul Konken C, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schäfers M, Sorokin L, Haufe G.
Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors.
15 Jul 2023, https://doi.org/10.1016/j.bmc.2023.117350
Kaps J, Georgieva VS, Oberholz L, Kribs A, Brachvogel B, Keller T.
Human preterm colostrum stimulates outgrowth in neurogenic tissue.
11 Jul 2023, https://doi.org/10.1038/s41390-023-02721-z
Etich J, Semler O, Stevenson NL, Stephan A, Besio R, Garibaldi N, Reintjes N, Dafinger C, Liebau MC, Baumann U, Mörgelin M, Forlino A, Stephens DJ, Netzer C, Zaucke F, Rehberg M.
TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
10 Jul 2023, https://doi.org/10.15252/emmm.202317528
Li S, Kong Z, Ma B, Wang H, Han Y, Zhao H, Shi X, Lv P, Yue H, Grässel S, Yin L.
Low miR-182-5p Expressing Extracellular Vesicles Derived From Human Bone Marrow Stromal Cells of Subjects With Steroid-Induced Osteonecrosis of the Femoral Head Aggravate Disease Progression.
1 Jul 2023, https://doi.org/10.1002/jbmr.4823
Becker L, Montes-Mojarro IA, Layland SL, Nsair A, Fend F, Marzi J, Schenke-Layland K.
Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy.
1 Jul 2023, https://doi.org/10.1152/ajpcell.00209.2023
Zhu M, Metzen F, Hopkinson M, Betz J, Heilig J, Sodhi J, Imhof T, Niehoff A, Birk DE, Izu Y, Krüger M, Pitsillides AA, Altmüller J, van Osch GJVM, Straub V, Schreiber G, Paulsson M, Koch M, Brachvogel B.
Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation.
28 Jun 2023, https://pubmed.ncbi.nlm.nih.gov/37485359/
Gude F, Froese J, Steffes G, Grobe K.
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis.
28 Jun 2023, https://doi.org/10.1042/bst20220719
Bodescu MA, Aretz J, Grison M, Rief M, Fässler R.
Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond.
27 Jun 2023, https://doi.org/10.1073/pnas.2218116120
Hammersen T, Buchert J, Zietzschmann S, Diederichs S, Richter W.
Inverse Regulation of Cartilage Neogenesis at Physiologically Relevant Calcium Conditions by Human Articular Chondrocytes and Mesenchymal Stromal Cells.
18 Jun 2023, https://doi.org/10.3390/cells12121659
Lu CE, Levey RE, Ghersi G, Schueller N, Liebscher S, Layland SL, Schenke-Layland K, Duffy GP, Marzi J.
Monitoring the macrophage response towards biomaterial implants using label-free imaging.
13 Jun 2023, https://doi.org/10.1016/j.mtbio.2023.100696
Etich J, Semler O, Stevenson NL, Stephan A, Besio R, Garibaldi N, Reintjes N, Dafinger C, Liebau MC, Baumann U, Mörgelin M, Forlino A, Stephens DJ, Netzer C, Zaucke F, Rehberg M.
TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
9 Jun 2023, https://pubmed.ncbi.nlm.nih.gov/37292039/
Esho T, Kobbe B, Tufa SF, Keene DR, Paulsson M, Wagener R.
The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal-Epidermal Junction of Mouse Skin.
5 Apr 2023, https://pubmed.ncbi.nlm.nih.gov/37047755/
Becker L, Lu CE, Montes-Mojarro IA, Layland SL, Khalil S, Nsair A, Duffy GP, Fend F, Marzi J, Schenke-Layland K.
Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra.
16 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36931422/
Hassan N, Bückreiß N, Efing J, Schulz-Fincke M, König P, Greve B, Bendas G, Götte M.
The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.
16 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36980251/
Kuhn A, Riegger J, Teixeira GQ, Huber-Lang M, Lambris JD, Neidlinger-Wilke C, Brenner RE.
Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells.
13 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36980228/
Morgner J, Bornes L, Hahn K, López-Iglesias C, Kroese L, Pritchard CEJ, Vennin C, Peters PJ, Huijbers I, van Rheenen J.
A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors
6 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36905927/
Meier M, Gupta M, Akgül S, McDougall M, Imhof T, Nikodemus D, Reuten R, Moya-Torres A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Mörgelin M, Poole K, Antebi A, Koch M, Stetefeld J.
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
3 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36869049/
Empere M, Wang X, Prein C, Aspberg A, Moser M, Oohashi T, Clausen-Schaumann H, Aszodi A, Alberton P.
Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix.
2 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36937743/
Hassan N, Efing J, Kiesel L, Bendas G, Götte M.
The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans.
28 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36900315/
Manikowski D, Steffes G, Froese J, Exner S, Ehring K, Gude F, Di Iorio D, Wegner SV, Grobe K.
Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions.
22 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36911531/
Fan L, Ren Y, Emmert S, Vučković I, Stojanovic S, Najman S, Schnettler R, Barbeck M, Schenke-Layland K, Xiong X.
The Use of Collagen-Based Materials in Bone Tissue Engineering.
13 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36835168/
Gude F, Froese J, Manikowski D, Di Iorio D, Grad JN, Wegner S, Hoffmann D, Kennedy M, Richter RP, Steffes G, Grobe K.
Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient.
10 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36765094/
Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L.
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy.
1 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36440857/
Riegger J, Joos H, Möhler V, Leucht F, Rading K, Kubisch C, Ignatius A, Huber-Lang M, Brenner RE.
Functional Loss of Terminal Complement Complex Protects Rabbits from Injury-Induced Osteoarthritis on Structural and Cellular Level.
22 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36830586/
Espinoza-Sanchez NA, Troschel F, Greve B, Götte M.
Proteoglycan Expression Studied by MicroRNAs.
21 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36662477/
Zeng-Brouwers J, Huber LS, Merline R, Trebicka J, Wygrecka M, Schaefer L.
Evaluation of the In Vitro and In Vivo Effects of Biglycan in Innate Immunity.
21 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36662466/
Schäfer N, Grässel S.
New refinements aim to optimize articular cartilage tissue engineering.
5 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36604597/
Spanou CES, Wohl AP, Doherr S, Correns A, Sonntag N, Lütke S, Mörgelin M, Imhof T, Gebauer JM, Baumann U, Grobe K, Koch M, Sengle G.
Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation.
1 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36563024/
2022
Urbanczyk M, Jeyagaran A, Zbinden A, Lu CE, Marzi J, Kuhlburger L, Nahnsen S, Layland SL, Duffy G, Schenke-Layland K.
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro.
30 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36592738/
Wank I, Niedermair T, Kronenberg D, Stange R, Brochhausen C, Hess A, Grässel S.
Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia.
28 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36613952/
Schäfer N, Grässel S.
Targeted therapy for osteoarthritis: progress and pitfalls.
28 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36456832/
Rapp AE, Zaucke F.
Cartilage Extracellular Matrix-derived Matrikines in Osteoarthritis.
26 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36571440/
Willenborg S, Injarabian L, Eming SA.
Role of Macrophages in Wound Healing.
1 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36041784/
Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L.
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy.
28 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36440857/
Fromme JE, Dummer R, Mauch C, Zigrino P.
Tenascin C is a valuable marker for melanoma progression independent of mutational status and MAPK inhibitor therapy.
27 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36437681/
Stöckl S, Reichart J, Zborilova M, Johnstone B, Grässel S.
Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes.
16 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36430655/
Forte-Gomez HF, Gioia R, Tonelli F, Kobbe B, Koch P, Bloch W, Paulsson M, Zaucke F, Forlino A, Wagener R.
Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta.
14 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36452329/
Buchert JM, Lotz B, Diederichs S, Richter W.
Adipose-Derived Stromal Cells: Isolation, Expansion, and Differentiation.
11 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36355286/
Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B.
EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
8 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36351433/
Kümper M, Zamek J, Steinkamp J, Pach E, Mauch C, Zigrino P.
Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.
23 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36162272/
Onyeisi JOS, Lopes CC, Götte M.
Role of syndecan-4 in breast cancer pathophysiology.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36094435/
Przyklenk M, Heumüller SE, Freiburg C, Lütke S, Sengle G, Koch M, Paulsson M, Schiavinato A, Wagener R.
Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36185380/
Kümper M, Steinkamp J, Zigrino P.
Metalloproteinases in dermal homeostasis.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36094433/
Riegger J, Maurer S, Pulasani S, Brenner RE.
Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage.
9 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36159664/
Willenborg S, Injarabian L, Eming SA.
Role of Macrophages in Wound Healing.
30 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36041784/
Zhang JL, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda HM, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M.
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
22 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36007682/
Zhang JL, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda HM, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M.
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
22 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36007682/
Wang C, Stöckl S, Li S, Herrmann M, Lukas C, Reinders Y, Sickmann A, Grässel S.
Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs.
11 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36010568/
Ivanova EL, Costa B, Eisemann T, Lohr S, Boskovic P, Eichwald V, Meckler J, Jugold M, Orian-Rousseau V, Peterziel H, Angel P.
CD44 expressed by myeloid cells promotes glioma invasion.
4 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/35992852/
Marzi J, Munnig Schmidt EC, Brauchle EM, Wissing TB, Bauer H, Serrero A, Söntjens SHM, Bosman AW, Cox MAJ, Smits AIPM, Schenke-Layland K.
Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering.
17 May 2022, https://pubmed.ncbi.nlm.nih.gov/35656396/