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12 Doctoral Candidate positions – MSCA – “Cellular Homeostasis ANd AGing in Connective TissuE Disorders” (CHANGE) in the framework of the Horizon Europe Marie Curie Doctoral Network

CHANGE is a Marie Sklodowska-Curie Doctoral Network (MSCA-DN) focused on investigating connective tissue (CT) disorders to identify key players in age-related decline in physiological functions to develop therapeutic strategies and identify treatment targets for common diseases and frailty associated with aging. It is part of Horizon EUROPE programme of the European Union and 12 Doctoral Candidates (DC) will be appointed for 36 months each.

CHANGE project – summary

Lifespan has significantly increased but age-related disorders severely limit healthy aging and quality of life, and are a serious burden for the society. Musculoskeletal, cardio- and cerebrovascular failure are hallmarks of physical and cognitive decline in the elderly, but importantly, are also common traits in several early onset hereditary connective tissue disorders.

In CHANGE, 12 young scientists will combine skills in musculoskeletal and vascular developmental and cellular biology and pathobiology related to aging, with expertise in cell culture, animal models, -omics, innovative high-resolution imaging and functional techniques. Exchange of knowledge and multidisciplinary collaboration between these fields of research and partners within the consortium will provide the skills, multidisciplinary knowledge and on-the-job training experience necessary to tackle the main aspects of biology of aging and age-related disorders affecting bone, cartilage, muscle and vasculature.

PhD positions

The consortium consists of partners from academia and industry with excellent scientific qualifications in multiple disciplines. In total, there are 12 open PhD positions for DCs within CHANGE. Each DC will be appointed at one of the consortium partners but secondments and regular meetings will be performed at other partners to ensure multidisciplinary training and close collaboration. An ideal DC candidate will hold a Master’s degree with excellent marks from her/his previous studies and experience in one or more of the relevant broad research fields will be an advantage. Excellent written and oral communication skills in English are essential. The DCs will start their projects between September 2022 and March 2023.

More details here.

To apply for this position, send your CV, motivation letter and at least a reference letter to the following email address: change_project.msca@unipv.it

Please state the DC reference (CHANGE DC number) in the subject line. If you would like to apply for more than one position, please indicate your first and second preference.

Short listed Applicants will be interview by the Trainee Committee.

Structure-function analysis of a prominent target in fibrosis: the C-terminal maturation complex of fibrillar collagens

The biosynthesis of fibrillar collagens is severely deregulated in fibrosis, the common and deleterious outcome of a great diversity of tissue injuries. A better understanding of the various steps leading from the synthesis of individual procollagen chains to collagen fibrils would greatly benefit the development of new therapeutic tools. In the P3-complex project, we focus on the C-terminal proteolytic maturation of fibrillar procollagens in order to:
– better understand, at the molecular level, how the various components of the maturation complex (substrate, protease, regulatory proteins) associate and work together. This is done mainly by cryo-electron microscopy and through a combination of biochemical/biophysical approaches.
– learn more about how this complex affects tissue biology and extracellular matrix remodelling using transcriptomics, targeted mass spectrometry and biochemical assays.
This project is funded by the French Research Agency (ANR) and is performed in collaboration with the OPIC (Oxford Particle Imaging Center) facility in Oxford for cryo-EM and with the University Hospital of Dijon for fibrosis samples. It will contribute to optimize innovative tools, currently under development in the group, to diagnose and treat fibrosis.

Skills :
– Excellent theoritical and practical knowledge of molecular biology and protein biochemistry
– Experience in running protein-protein interaction analyses (ideally SPR) and biochemical assays to measure protein concentrations (ELISA, targeted mass spectrometry)
– Knowledge in structural biology; previous experience in cryo-EM would be an advantage
– Knowledge in extracellular matrix biology

More details here. Download the flyer.

We invite highly motivated candidates to apply directly on the above website (detailed CV with publication list and names of 2 references, cover letter) before October 15, 2022. The position is already open and can start immediately.

Laboratoire de Biologie Tissulaire et Ingénierie thérapeutique
Institut de Biologie et Chimie des Protéines
Unité Mixte de Recherche 5305 – CNRS / Université Lyon 1
https://lbti.ibcp.fr/

Obituary

In memory of

Prof. Dr. Dr. h.c. Klaus Kühn

*1.5.1927     † 7.4.2022

 

Klaus Kühn was a pioneer in collagen research with landmark discoveries in the collagen field, who shaped a sustainable extracellular matrix research in Germany and throughout the world. The passionate collagen scientist was fascinated by the collagen tripelhelix and was always a leading, highly motivating figure in the field who encouraged generations of young people to climb apparently unsurmountable summits.

Somehow, it happened that every chair in matrix biology research in Germany came from or went through Klaus Kühn‘s lab. The German Society for Matrix Biology and the worldwide matrix biology community is greatly saddened by the passing of Klaus Kühn.

 

Klaus Kühn had managed to establish an extremely successful international research center while maintaining a kind and collegial atmosphere within the department, welcoming students and scientists from all over the world. This was unique in the highly hierarchical academic structure in Germany at that time. Klaus Kühn was proud to be a typical chemist but he welcomed initiatives to approach connective tissue research from many different angles and he was always very interested in medical issues. He enjoyed scientific discussions as well as playing tennis with the members of his department. There is no doubt that he had a profound influence on our scientific, academic and personal life.

Monique Aumailley and Thomas Krieg

Er hinterlässt uns allen das Bild einer eindrücklichen, großzügigen, immer bescheidenen und liebenswürdigen Forscherpersönlichkeit. Sein Lebenswerk umfasst eine große Zahl von Wissenschaftlern, deren Entwicklung und Karriere er nachhaltig beeinflusst hat, eine zusätzliche Leistung, die alles andere als eine Selbstverständlichkeit ist. Wir alle sind ihm dafür zu Dank verpflichtet.

Peter Bruckner

Er war ein ausgezeichneter Lehrmeister, der wissenschaftliche Expertise mit einer fürsorglichen Menschlichkeit verband. Unvergesslich ist, wie er junge Wissenschaftler in die Wissenschaftsgemeinde der Extrazellulären Matrix integrierte. Der offene Wissenschaftsaustausch und die angenehme Umgebung auf Matrix-Tagungen ist auch sein Verdienst. Für sein prägendes Vorbild, Wissenschaft menschlich zu machen, bin ich ihm sehr dankbar. Ich bewahre ihn in Erinnerung.

Johannes Eble

Klaus Kühn was a pioneer, a titan of collagen research, and an excellent teacher and mentor. His scientific heritage and mentorship left lasting marks on connective tissue research, both in- and outside Germany. Even after his retirement, Klaus Kühn often visited his beloved Max Planck Institute of Biochemistry and always stopped by in my department to talk about the latest breakthroughs in matrix and adhesion research. His visits, discussions, support and advice will always remain in my memory.

Reinhard Fässler

Nicht nur die Wissenschaft, sondern auch viele muntere und warmherzige Treffen hat mich mit Klaus Kühn verbunden. Es sind nicht zuletzt diese Runden in anspruchsvoller Konversation und freundschaftlich, verbindlicher Atmosphäre, die uns in Erinnerung bleiben und die uns deutlich machen, welch menschlicher Verlust der fast gemeinsame Tod von Barbara und Klaus für uns bedeutet.

Verena Gauss-Müller & Peter Müller

I first got to know Klaus Kühn in 1983 when I joined Rupert Timpl´s group in the Kühn department in Martinsried. Later there were many more meetings, in particular at the famous retreats at Schloss Ringberg. Klaus was an outstanding scientist, but also a very kind and supportive mentor. I much appreciated the generosity with which he led his department. He gave us great freedom and a main priority was always the development of his younger coworkers. For this reason many of us stayed as long as ever possible. He became my role model with regard to scientific leadership. I feel deep sorrow.

Mats Paulsson

Klaus Kühn war für uns immer ein Fixpunkt als brillanter, stimulierender und immer neugieriger Wissenschaftler. Es war ein Erlebnis in seiner Abteilung, auch wenn er es einem nicht immer ganz leicht machte. Ein besonderer Mensch der Güte und Menschlichkeit ausstrahlte und dabei versuchte, die nächste Generation zu fordern und das Beste in ihnen zu fördern. In diesem Sinne erfüllt uns der Verlust mit Trauer aber auch menschlicher Dankbarkeit.

Ernst Pöschl & Ulrike Mayer

Ich werde Klaus Kühn als Freund, verständnisvollen Doktorvater, effizienten Institutsleiter und großen Wissenschaftler in Erinnerung behalten, der nicht nur die Wissenschaftsszene in Deutschland entscheidend geprägt hat, sondern auch den nachfolgenden Generationen die Erkenntnis mitgegeben hat, zu welcher Tiefe, Freude und Erfolg koordinierte Forschung im Team führen kann.

Klaus von der Mark

If you also wish to submit a personal obituary contact us.

Publications

2022

Zhang JL, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda HM, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M.
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
22 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36007682/

Lückgen J, Raqué E, Reiner T, Diederichs S, Richter W
NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels
27 Apr 2022, https://pubmed.ncbi.nlm.nih.gov/35477424/

Chen NP, Aretz J, Fässler R
CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
25 Apr 2022, https://pubmed.ncbi.nlm.nih.gov/35469017/

Przyklenk M, Georgieva VS, Metzen F, Mostert S, Kobbe B, Callewaert B, Sengle G, Brachvogel B, Mecham RP, Paulsson M, Wagener R, Koch M, Schiavinato A
LTBP1 promotes fibrillin incorporation into the extracellular matrix
19 Apr 2022, https://pubmed.ncbi.nlm.nih.gov/35452817/

Dreiner M, Munk T, Zaucke F, Liphardt AM, Niehoff A
Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals
19 Apr 2022, https://pubmed.ncbi.nlm.nih.gov/35440750/

Martin IM, Nava MM, Wickström SA, Gräter F
ATP allosterically stabilizes integrin-linked kinase for efficient force generation
8 Mar 2022, https://pubmed.ncbi.nlm.nih.gov/35259013/

Strauß T, Greve B, Gabriel M, Achmad N, Schwan D, Espinoza-Sanchez NA, Laganà AS, Kiesel L, Poutanen M, Götte M, Schäfer SD
Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis
5 Mar 2022, https://pubmed.ncbi.nlm.nih.gov/35269992/

Rosendahl AH, Schönborn K, Krieg T
Pathophysiology of systemic sclerosis (scleroderma)
2 Mar 2022, https://pubmed.ncbi.nlm.nih.gov/35234358/

Loustau T, Abou-Faycal C, Erne W, Zur Wiesch PA, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G
Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, "MAREMO"
26 Feb 2022, https://pubmed.ncbi.nlm.nih.gov/35227929/

Reuten R, Mayorca-Guiliani AE, Erler JT
Matritecture: Mapping the extracellular matrix architecture during health and disease
3 Feb 2022, https://pubmed.ncbi.nlm.nih.gov/35243299/

Hilgers K, Ibrahim SA, Kiesel L, Greve B, Espinoza-Sánchez NA, Götte M
Differential Impact of Membrane-Bound and Soluble Forms of the Prognostic Marker Syndecan-1 on the Invasiveness, Migration, Apoptosis, and Proliferation of Cervical Cancer Cells
27 Jan 2022, https://pubmed.ncbi.nlm.nih.gov/35155241/

Morcos YAT, Lütke S, Tenbieg A, Hanisch FG, Pryymachuk G, Piekarek N, Hoffmann T, Keller T, Janoschek R, Niehoff A, Zaucke F, Dötsch J, Hucklenbruch-Rother E, Sengle G
Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin
25 Jan 2022, https://pubmed.ncbi.nlm.nih.gov/35079041/

Rösch G, Muschter D, Taheri S, El Bagdadi K, Dorn C, Meurer A, Zaucke F, Schilling AF, Grässel S, Straub RH, Jenei-Lanzl Z
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis
13 Jan 2022, https://pubmed.ncbi.nlm.nih.gov/35095883/

Kahl I, Mense J, Finke C, Boller AL, Lorber C, Győrffy B, Greve B, Götte M, Espinoza-Sánchez NA
The cell cycle-related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients
10 Jan 2022, https://pubmed.ncbi.nlm.nih.gov/35014077/

Böttcher RT, Strohmeyer N, Aretz J, Fässler R.
New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
7 Jan 2022, https://pubmed.ncbi.nlm.nih.gov/34996844/

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