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Universitätsklinikum Freiburg
- Naturwissenschaftliche*n Doktorand*in (m/w/d)
- Naturwissenschaftliche*n Doktorand*in und/oder Post-Doktorand*in (m/w/d)
Universität Lyon
Obituary
In memory of
Prof. Dr. Dr. h.c. Klaus Kühn
*1.5.1927 † 7.4.2022
Klaus Kühn was a pioneer in collagen research with landmark discoveries in the collagen field, who shaped a sustainable extracellular matrix research in Germany and throughout the world. The passionate collagen scientist was fascinated by the collagen tripelhelix and was always a leading, highly motivating figure in the field who encouraged generations of young people to climb apparently unsurmountable summits.
Somehow, it happened that every chair in matrix biology research in Germany came from or went through Klaus Kühn‘s lab. The German Society for Matrix Biology and the worldwide matrix biology community is greatly saddened by the passing of Klaus Kühn.
Klaus Kühn had managed to establish an extremely successful international research center while maintaining a kind and collegial atmosphere within the department, welcoming students and scientists from all over the world. This was unique in the highly hierarchical academic structure in Germany at that time. Klaus Kühn was proud to be a typical chemist but he welcomed initiatives to approach connective tissue research from many different angles and he was always very interested in medical issues. He enjoyed scientific discussions as well as playing tennis with the members of his department. There is no doubt that he had a profound influence on our scientific, academic and personal life.
Monique Aumailley and Thomas Krieg
Er hinterlässt uns allen das Bild einer eindrücklichen, großzügigen, immer bescheidenen und liebenswürdigen Forscherpersönlichkeit. Sein Lebenswerk umfasst eine große Zahl von Wissenschaftlern, deren Entwicklung und Karriere er nachhaltig beeinflusst hat, eine zusätzliche Leistung, die alles andere als eine Selbstverständlichkeit ist. Wir alle sind ihm dafür zu Dank verpflichtet.
Peter Bruckner
Er war ein ausgezeichneter Lehrmeister, der wissenschaftliche Expertise mit einer fürsorglichen Menschlichkeit verband. Unvergesslich ist, wie er junge Wissenschaftler in die Wissenschaftsgemeinde der Extrazellulären Matrix integrierte. Der offene Wissenschaftsaustausch und die angenehme Umgebung auf Matrix-Tagungen ist auch sein Verdienst. Für sein prägendes Vorbild, Wissenschaft menschlich zu machen, bin ich ihm sehr dankbar. Ich bewahre ihn in Erinnerung.
Johannes Eble
Klaus Kühn was a pioneer, a titan of collagen research, and an excellent teacher and mentor. His scientific heritage and mentorship left lasting marks on connective tissue research, both in- and outside Germany. Even after his retirement, Klaus Kühn often visited his beloved Max Planck Institute of Biochemistry and always stopped by in my department to talk about the latest breakthroughs in matrix and adhesion research. His visits, discussions, support and advice will always remain in my memory.
Reinhard Fässler
Nicht nur die Wissenschaft, sondern auch viele muntere und warmherzige Treffen hat mich mit Klaus Kühn verbunden. Es sind nicht zuletzt diese Runden in anspruchsvoller Konversation und freundschaftlich, verbindlicher Atmosphäre, die uns in Erinnerung bleiben und die uns deutlich machen, welch menschlicher Verlust der fast gemeinsame Tod von Barbara und Klaus für uns bedeutet.
Verena Gauss-Müller & Peter Müller
I first got to know Klaus Kühn in 1983 when I joined Rupert Timpl´s group in the Kühn department in Martinsried. Later there were many more meetings, in particular at the famous retreats at Schloss Ringberg. Klaus was an outstanding scientist, but also a very kind and supportive mentor. I much appreciated the generosity with which he led his department. He gave us great freedom and a main priority was always the development of his younger coworkers. For this reason many of us stayed as long as ever possible. He became my role model with regard to scientific leadership. I feel deep sorrow.
Mats Paulsson
Klaus Kühn war für uns immer ein Fixpunkt als brillanter, stimulierender und immer neugieriger Wissenschaftler. Es war ein Erlebnis in seiner Abteilung, auch wenn er es einem nicht immer ganz leicht machte. Ein besonderer Mensch der Güte und Menschlichkeit ausstrahlte und dabei versuchte, die nächste Generation zu fordern und das Beste in ihnen zu fördern. In diesem Sinne erfüllt uns der Verlust mit Trauer aber auch menschlicher Dankbarkeit.
Ernst Pöschl & Ulrike Mayer
Ich werde Klaus Kühn als Freund, verständnisvollen Doktorvater, effizienten Institutsleiter und großen Wissenschaftler in Erinnerung behalten, der nicht nur die Wissenschaftsszene in Deutschland entscheidend geprägt hat, sondern auch den nachfolgenden Generationen die Erkenntnis mitgegeben hat, zu welcher Tiefe, Freude und Erfolg koordinierte Forschung im Team führen kann.
Klaus von der Mark
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Publications
2024
Brockhaus K, Hemsen I, Jauch-Speer SL, Niland S, Vogl T, Eble JA
Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis
15 Aug 2024, https://doi.org/10.3389/fcell.2024.1448725
Mao Y, Wickström SA
Mechanical state transitions in the regulation of tissue form and function
1 Aug 2024, https://doi.org/10.1038/s41580-024-00719-x
Mielke Cabello LA, Meresman G, Darici D, Carnovale N, Heitkötter B, Schulte M, Espinoza-Sánchez NA, Le QK, Kiesel L, Schäfer SD, Götte M
Assessment of the Ferroptosis Regulators: Glutathione Peroxidase 4, Acyl-Coenzyme A Synthetase Long-Chain Family Member 4, and Transferrin Receptor 1 in Patient-Derived Endometriosis Tissue
21 Jul 2024, https://doi.org/10.3390/biom14070876
Reiter L, Niehoff N, Weiland D, Helbig D, Eming SA, Krieg T, Etich J, Brachvogel B, Wiesner RJ, Knuever J.
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
14 Jul 2024, https://doi.org/10.1016/j.matbio.2024.07.002
Kuhn A, Huber-Lang M, Weckbach S, Riegger J, Teixeira GQ, Rasche V, Fiedler J, Neidlinger-Wilke C, Brenner RE
Analysis of Intervertebral Disc Degeneration Induced by Endplate Drilling or Needle Puncture in Complement C6-Sufficient and C6-Deficient Rabbits
3 Jul 2024, https://doi.org/10.3390/biomedicines12081692
Knobler R, Geroldinger-Simić M, Kreuter A, Hunzelmann N, Moinzadeh P, Rongioletti F, Denton C, Mouthon L, Cutolo M, Smith V, Gabrielli A, Bagot M, Olesen AB, Foeldvari I, Jalili A, Kähäri VM, Kárpáti S, Kofoed K, Olszewska M, Panelius J, Quaglino P, Seneschal J, Sticherling M, Sunderkötter C, Tanew A, Wolf P, Worm M, Skrok A, Rudnicka L, Krieg T
Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxoedema and scleroedema
1 Jul 2024, https://doi.org/10.1111/jdv.19937
Schmidt L, Saynisch M, Hoegsbjerg C, Schmidt A, Mackey A, Lackmann JW, Müller S, Koch M, Brachvogel B, Kjaer M, Antczak P, Krüger M.
Spatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaptation at the muscle-tendon transition zone.Spatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaptation at the muscle-tendon transition zone.
19 Jun 2024, https://doi.org/10.1016/j.celrep.2024.114374
Jeyagaran A, Urbanczyk M, Layland SL, Weise F, Schenke-Layland K
Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA
13 Jun 2024, https://doi.org/10.1038/s41598-024-64346-4
Niessen CM, Manning ML, Wickström SA
Mechanochemical Principles of Epidermal Tissue Dynamics
10 Jun 2024, https://doi.org/10.1101/cshperspect.a041518
Conradt G, Hausser I, Nyström A
Epidermal or Dermal Collagen VII Is Sufficient for Skin Integrity: Insights to Anchoring Fibril Homeostasis
1 Jun 2024, https://doi.org/10.1016/j.jid.2023.11.003
Sohn R, Assar T, Kaufhold I, Brenneis M, Braun S, Junker M, Zaucke F, Pongratz G, Jenei-Lanzl Z
Osteoarthritis patients exhibit an autonomic dysfunction with indirect sympathetic dominance
16 May 2024, https://doi.org/10.1186/s12967-024-05258-9
Hartmann B, Fleischhauer L, Nicolau M, Jensen THL, Taran FA, Clausen-Schaumann H, Reuten R
Profiling native pulmonary basement membrane stiffness using atomic force microscopy
1 May 2024, https://doi.org/10.1038/s41596-024-00955-7
Ruths L, Huber-Lang M, Schulze-Tanzil G, Riegger J
Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression
1 May 2024, https://doi.org/10.1016/j.joca.2024.01.004
Przyklenk M, Karmacharya S, Bonasera D, Pasanen-Zentz AL, Kmoch S, Paulsson M, Wagener R, Liccardi G, Schiavinato A
ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder
23 Apr 2024, https://doi.org/10.1038/s41598-024-59901-y
Ehlers SF, Manikowski D, Steffes G, Ehring K, Gude F, Grobe K
A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor
9 Apr 2024, https://doi.org/10.3390/jdb12020011
Schmidt S, Klampfleuthner FAM, Renkawitz T, Diederichs S.
Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis.
7 Apr 2024, https://doi.org/10.1016/j.ejcb.2024.151412
Diederichs S, Dreher SI, Nüesch SA, Schmidt S, Merle C, Richter W
Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept
5 Apr 2024, https://doi.org/10.1186/s13287-024-03710-7
Zeyer KA, Bornert O, Nelea V, Bao X, Leytens A, Sharoyan S, Sengle G, Antonyan A, Bruckner-Tuderman L, Dengjel J, Reinhardt DP, Nyström A
Dipeptidyl Peptidase-4-Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix
1 Apr 2024, https://doi.org/10.1016/j.jid.2024.03.020
Mayr CH, Sengupta A, Asgharpour S, Ansari M, Pestoni JC, Ogar P, Angelidis I, Liontos A, Rodriguez-Castillo JA, Lang NJ, Strunz M, Porras-Gonzalez D, Gerckens M, De Sadeleer LJ, Oehrle B, Viteri-Alvarez V, Fernandez IE, Tallquist M, Irmler M, Beckers J, Eickelberg O, Stoleriu GM, Behr J, Kneidinger N, Wuyts WA, Wasnick RM, Yildirim AÖ, Ahlbrecht K, Morty RE, Samakovlis C, Theis FJ, Burgstaller G, Schiller HB
Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts
8 Feb 2024, https://doi.org/10.1183/13993003.01326-2023
Liphardt AM, Godonou ET, Dreiner M, Mündermann A, Tascilar K, Djalal N, Heer M, Schett G, Zaucke F, Niehoff A
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals. Osteoarthritis Cartilage
1 Feb 2024, https://doi.org/10.1016/j.joca.2023.11.007
Villeneuve C, Hashmi A, Ylivinkka I, Lawson-Keister E, Miroshnikova YA, Pérez-González C, Myllymäki SM, Bertillot F, Yadav B, Zhang T, Matic Vignjevic D, Mikkola ML, Manning ML, Wickström SA
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
1 Feb 2024, https://doi.org/10.1038/s41556-023-01332-4
Obermann WMJ, König S, Feickert MK, Sanz-Soler R, Eble JA
A change of rhodocytin's suprastructure turns the agonist into an antagonist of tumor cell induced platelet aggregation
31 Jan 2024, https://doi.org/10.1096/fj.202301175r
Injarabian L, Willenborg S, Welcker D, Sanin DE, Pasparakis M, Kashkar H, Eming SA
FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue
1 Jan 2024, https://doi.org/10.1016/j.jid.2023.06.203
2023
Gehle PF, Satzinger S, Willenborg S, Eming SA
Isolation of dermal adipocytes from mouse skin for biochemical analysis
15 Dec 2023, https://doi.org/10.1016/j.xpro.2023.102765
Lang NJ, Gote-Schniering J, Porras-Gonzalez D, Yang L, De Sadeleer LJ, Jentzsch RC, Shitov VA, Zhou S, Ansari M, Agami A, Mayr CH, Hooshiar Kashani B, Chen Y, Heumos L, Pestoni JC, Molnar ES, Geeraerts E, Anquetil V, Saniere L, Wögrath M, Gerckens M, Lehmann M, Yildirim AÖ, Hatz R, Kneidinger N, Behr J, Wuyts WA, Stoleriu MG, Luecken MD, Theis FJ, Burgstaller G, Schiller HB
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis
6 Dec 2023, https://doi.org/10.1126/scitranslmed.adh0908
Satzinger S, Willenborg S, Ding X, Klose CSN, Radtke D, Voehringer D, Eming SA
Type 2 Immunity Regulates Dermal White Adipose Tissue Function
1 Dec 2023, https://doi.org/10.1016/j.jid.2023.05.017
Danyukova T, Alimy AR, Velho RV, Yorgan TA, Di Lorenzo G, von Kroge S, Tidow H, Wiegert JS, Hermans-Borgmeyer I, Schinke T, Rolvien T, Pohl S
Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage
1 Dec 2023, https://doi.org/10.1016/j.bone.2023.116927
Aretz J, Aziz M, Strohmeyer N, Sattler M, Fässler R
Talin and kindlin use integrin tail allostery and direct binding to activate integrins
1 Dec 2023, https://doi.org/10.1038/s41594-023-01139-9
Sawant M, Wang F, Koester J, Niehoff A, Nava MM, Lundgren-Akerlund E, Gullberg D, Leitinger B, Wickström S, Eckes B, Krieg T
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis
1 Nov 2023, https://doi.org/10.1136/ard-2023-224129
Leuschner G, Semenova A, Mayr CH, Kapellos TS, Ansari M, Seeliger B, Frankenberger M, Kneidinger N, Hatz RA, Hilgendorff A, Prasse A, Behr J, Mann M, Schiller HB
Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis
27 Oct 2023, https://doi.org/10.1016/j.isci.2023.108345
Riegger J, Brenner RE
Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes
19 Oct 2023, https://doi.org/10.3390/biomedicines11102804
Wang C, Stöckl S, Pattappa G, Schulz D, Hofmann K, Ilic J, Reinders Y, Bauer RJ, Sickmann A, Grässel S
Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia.
16 Oct 2023, https://doi.org/10.3390/biomedicines11102804
Sigle M, Rohlfing AK, Kenny M, Scheuermann S, Sun N, Graeßner U, Haug V, Sudmann J, Seitz CM, Heinzmann D, Schenke-Layland K, Maguire PB, Walch A, Marzi J, Gawaz MP.
Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution.
19 Sep 2023, https://doi.org/10.1038/s41467-023-41417-0
Prag HA, Murphy MP, Krieg T.
Sox-2 positive cells identified in lymph nodes from endometriosis patients may play a role in the disease pathogenesis.
1 Sep 2023, https://doi.org/10.1016/j.ejogrb.2023.07.017
Anderle N, Schäfer-Ruoff F, Staebler A, Kersten N, Koch A, Önder C, Keller AL, Liebscher S, Hartkopf A, Hahn M, Templin M, Brucker SY, Schenke-Layland K, Schmees C.
Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment.
18 Aug 2023, https://doi.org/10.1186/s13046-023-02782-2
Luik AL, Hannocks MJ, Loismann S, Kapupara K, Cerina M, van der Stoel M, Tsytsyura Y, Glyvuk N, Nordenvall C, Klingauf J, Huveneers S, Meuth S, Jakobsson L, Sorokin L.
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication.
1 Aug 2023, https://doi.org/10.1016/j.matbio.2023.06.001
Hsu CP, Aretz J, Hordeichyk A, Fässler R, Bausch AR.
Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes.
1 Aug 2023, https://doi.org/10.1073/pnas.2301881120
Ewald CY, Nyström A.
Mechanotransduction through hemidesmosomes during aging and longevity.
1 Aug 2023, https://doi.org/10.1242/jcs.260987
Rösch G, Zaucke F, Jenei-Lanzl Z.
Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis.
1 Aug 2023, https://doi.org/10.1152/ajpcell.00039.2023
Injarabian L, Willenborg S, Welcker D, Sanin DE, Pasparakis M, Kashkar H, Eming SA.
FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue.
27 Jul 2023, https://doi.org/10.1016/j.jid.2023.06.203
Brenneis M, Junker M, Sohn R, Braun S, Ehnert M, Zaucke F, Jenei-Lanzl Z, Meurer A.
Patellar malalignment correlates with increased pain and increased synovial stress hormone levels-A cross-sectional study.
27 Jul 2023, https://doi.org/10.1371/journal.pone.0289298
Sawant M, Wang F, Koester J, Niehoff A, Nava MM, Lundgren-Akerlund E, Gullberg D, Leitinger B, Wickström S, Eckes B, Krieg T.
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis.
21 Jul 2023, https://pubmed.ncbi.nlm.nih.gov/37479494/
Lau C, Muthu ML, Siddiqui IF, Li L, Reinhardt DP.
High fat diet has a protective sex-dependent effect on aortic aneurysm severity in a Marfan syndrome mouse model.
21 Jul 2023, https://doi.org/10.1016/j.cjca.2023.07.020
Burmeister M, Fraunenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, Kuhlmann T, Gross CC, Naik VN, Wiendl H, Klingauf J, Meissner F, Sorokin L.
Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function.
21 Jul 2023, https://doi.org/10.1126/sciadv.adg0686
Rafaeva M, Jensen ARD, Horton ER, Zornhagen KW, Strøbech JE, Fleischhauer L, Mayorca-Guiliani AE, Nielsen SR, Grønseth DS, Kuś F, Schoof EM, Arnes L, Koch M, Clausen-Schaumann H, Izzi V, Reuten R, Erler JT.
Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression.
18 Jul 2023, https://doi.org/10.3389/fimmu.2023.1154528
Paul Konken C, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schäfers M, Sorokin L, Haufe G.
Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors.
15 Jul 2023, https://doi.org/10.1016/j.bmc.2023.117350
Kaps J, Georgieva VS, Oberholz L, Kribs A, Brachvogel B, Keller T.
Human preterm colostrum stimulates outgrowth in neurogenic tissue.
11 Jul 2023, https://doi.org/10.1038/s41390-023-02721-z
Etich J, Semler O, Stevenson NL, Stephan A, Besio R, Garibaldi N, Reintjes N, Dafinger C, Liebau MC, Baumann U, Mörgelin M, Forlino A, Stephens DJ, Netzer C, Zaucke F, Rehberg M.
TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
10 Jul 2023, https://doi.org/10.15252/emmm.202317528
Li S, Kong Z, Ma B, Wang H, Han Y, Zhao H, Shi X, Lv P, Yue H, Grässel S, Yin L.
Low miR-182-5p Expressing Extracellular Vesicles Derived From Human Bone Marrow Stromal Cells of Subjects With Steroid-Induced Osteonecrosis of the Femoral Head Aggravate Disease Progression.
1 Jul 2023, https://doi.org/10.1002/jbmr.4823
Becker L, Montes-Mojarro IA, Layland SL, Nsair A, Fend F, Marzi J, Schenke-Layland K.
Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy.
1 Jul 2023, https://doi.org/10.1152/ajpcell.00209.2023
Zhu M, Metzen F, Hopkinson M, Betz J, Heilig J, Sodhi J, Imhof T, Niehoff A, Birk DE, Izu Y, Krüger M, Pitsillides AA, Altmüller J, van Osch GJVM, Straub V, Schreiber G, Paulsson M, Koch M, Brachvogel B.
Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation.
28 Jun 2023, https://pubmed.ncbi.nlm.nih.gov/37485359/
Gude F, Froese J, Steffes G, Grobe K.
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis.
28 Jun 2023, https://doi.org/10.1042/bst20220719
Bodescu MA, Aretz J, Grison M, Rief M, Fässler R.
Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond.
27 Jun 2023, https://doi.org/10.1073/pnas.2218116120
Hammersen T, Buchert J, Zietzschmann S, Diederichs S, Richter W.
Inverse Regulation of Cartilage Neogenesis at Physiologically Relevant Calcium Conditions by Human Articular Chondrocytes and Mesenchymal Stromal Cells.
18 Jun 2023, https://doi.org/10.3390/cells12121659
Lu CE, Levey RE, Ghersi G, Schueller N, Liebscher S, Layland SL, Schenke-Layland K, Duffy GP, Marzi J.
Monitoring the macrophage response towards biomaterial implants using label-free imaging.
13 Jun 2023, https://doi.org/10.1016/j.mtbio.2023.100696
Etich J, Semler O, Stevenson NL, Stephan A, Besio R, Garibaldi N, Reintjes N, Dafinger C, Liebau MC, Baumann U, Mörgelin M, Forlino A, Stephens DJ, Netzer C, Zaucke F, Rehberg M.
TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
9 Jun 2023, https://pubmed.ncbi.nlm.nih.gov/37292039/
Esho T, Kobbe B, Tufa SF, Keene DR, Paulsson M, Wagener R.
The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal-Epidermal Junction of Mouse Skin.
5 Apr 2023, https://pubmed.ncbi.nlm.nih.gov/37047755/
Becker L, Lu CE, Montes-Mojarro IA, Layland SL, Khalil S, Nsair A, Duffy GP, Fend F, Marzi J, Schenke-Layland K.
Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra.
16 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36931422/
Hassan N, Bückreiß N, Efing J, Schulz-Fincke M, König P, Greve B, Bendas G, Götte M.
The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.
16 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36980251/
Kuhn A, Riegger J, Teixeira GQ, Huber-Lang M, Lambris JD, Neidlinger-Wilke C, Brenner RE.
Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells.
13 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36980228/
Morgner J, Bornes L, Hahn K, López-Iglesias C, Kroese L, Pritchard CEJ, Vennin C, Peters PJ, Huijbers I, van Rheenen J.
A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors
6 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36905927/
Meier M, Gupta M, Akgül S, McDougall M, Imhof T, Nikodemus D, Reuten R, Moya-Torres A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Mörgelin M, Poole K, Antebi A, Koch M, Stetefeld J.
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
3 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36869049/
Empere M, Wang X, Prein C, Aspberg A, Moser M, Oohashi T, Clausen-Schaumann H, Aszodi A, Alberton P.
Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix.
2 Mar 2023, https://pubmed.ncbi.nlm.nih.gov/36937743/
Hassan N, Efing J, Kiesel L, Bendas G, Götte M.
The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans.
28 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36900315/
Manikowski D, Steffes G, Froese J, Exner S, Ehring K, Gude F, Di Iorio D, Wegner SV, Grobe K.
Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions.
22 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36911531/
Fan L, Ren Y, Emmert S, Vučković I, Stojanovic S, Najman S, Schnettler R, Barbeck M, Schenke-Layland K, Xiong X.
The Use of Collagen-Based Materials in Bone Tissue Engineering.
13 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36835168/
Gude F, Froese J, Manikowski D, Di Iorio D, Grad JN, Wegner S, Hoffmann D, Kennedy M, Richter RP, Steffes G, Grobe K.
Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient.
10 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36765094/
Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L.
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy.
1 Feb 2023, https://pubmed.ncbi.nlm.nih.gov/36440857/
Riegger J, Joos H, Möhler V, Leucht F, Rading K, Kubisch C, Ignatius A, Huber-Lang M, Brenner RE.
Functional Loss of Terminal Complement Complex Protects Rabbits from Injury-Induced Osteoarthritis on Structural and Cellular Level.
22 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36830586/
Espinoza-Sanchez NA, Troschel F, Greve B, Götte M.
Proteoglycan Expression Studied by MicroRNAs.
21 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36662477/
Zeng-Brouwers J, Huber LS, Merline R, Trebicka J, Wygrecka M, Schaefer L.
Evaluation of the In Vitro and In Vivo Effects of Biglycan in Innate Immunity.
21 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36662466/
Schäfer N, Grässel S.
New refinements aim to optimize articular cartilage tissue engineering.
5 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36604597/
Spanou CES, Wohl AP, Doherr S, Correns A, Sonntag N, Lütke S, Mörgelin M, Imhof T, Gebauer JM, Baumann U, Grobe K, Koch M, Sengle G.
Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation.
1 Jan 2023, https://pubmed.ncbi.nlm.nih.gov/36563024/
2022
Urbanczyk M, Jeyagaran A, Zbinden A, Lu CE, Marzi J, Kuhlburger L, Nahnsen S, Layland SL, Duffy G, Schenke-Layland K.
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro.
30 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36592738/
Schäfer N, Grässel S.
Targeted therapy for osteoarthritis: progress and pitfalls.
28 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36456832/
Wank I, Niedermair T, Kronenberg D, Stange R, Brochhausen C, Hess A, Grässel S.
Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia.
28 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36613952/
Rapp AE, Zaucke F.
Cartilage Extracellular Matrix-derived Matrikines in Osteoarthritis.
26 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36571440/
Willenborg S, Injarabian L, Eming SA.
Role of Macrophages in Wound Healing.
1 Dec 2022, https://pubmed.ncbi.nlm.nih.gov/36041784/
Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L.
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy.
28 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36440857/
Fromme JE, Dummer R, Mauch C, Zigrino P.
Tenascin C is a valuable marker for melanoma progression independent of mutational status and MAPK inhibitor therapy.
27 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36437681/
Stöckl S, Reichart J, Zborilova M, Johnstone B, Grässel S.
Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes.
16 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36430655/
Forte-Gomez HF, Gioia R, Tonelli F, Kobbe B, Koch P, Bloch W, Paulsson M, Zaucke F, Forlino A, Wagener R.
Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta.
14 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36452329/
Buchert JM, Lotz B, Diederichs S, Richter W.
Adipose-Derived Stromal Cells: Isolation, Expansion, and Differentiation.
11 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36355286/
Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Muiño-Mosquera L, Gulec EY, Gezdirici A, Braghetta P, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Schwarze U, Holmes KW, Hayflick SJ, Wiszniewski W, Nampoothiri S, Davis EC, Sakai LY, Sengle G, Callewaert B.
EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
8 Nov 2022, https://pubmed.ncbi.nlm.nih.gov/36351433/
Kümper M, Zamek J, Steinkamp J, Pach E, Mauch C, Zigrino P.
Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.
23 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36162272/
Kümper M, Steinkamp J, Zigrino P.
Metalloproteinases in dermal homeostasis.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36094433/
Onyeisi JOS, Lopes CC, Götte M.
Role of syndecan-4 in breast cancer pathophysiology.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36094435/
Przyklenk M, Heumüller SE, Freiburg C, Lütke S, Sengle G, Koch M, Paulsson M, Schiavinato A, Wagener R.
Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin.
12 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36185380/
Riegger J, Maurer S, Pulasani S, Brenner RE.
Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage.
9 Sep 2022, https://pubmed.ncbi.nlm.nih.gov/36159664/
Willenborg S, Injarabian L, Eming SA.
Role of Macrophages in Wound Healing.
30 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36041784/
Zhang JL, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda HM, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M.
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
22 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36007682/
Zhang JL, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda HM, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M.
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
22 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36007682/
Wang C, Stöckl S, Li S, Herrmann M, Lukas C, Reinders Y, Sickmann A, Grässel S.
Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs.
11 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/36010568/
Ivanova EL, Costa B, Eisemann T, Lohr S, Boskovic P, Eichwald V, Meckler J, Jugold M, Orian-Rousseau V, Peterziel H, Angel P.
CD44 expressed by myeloid cells promotes glioma invasion.
4 Aug 2022, https://pubmed.ncbi.nlm.nih.gov/35992852/
Marzi J, Munnig Schmidt EC, Brauchle EM, Wissing TB, Bauer H, Serrero A, Söntjens SHM, Bosman AW, Cox MAJ, Smits AIPM, Schenke-Layland K.
Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering.
17 May 2022, https://pubmed.ncbi.nlm.nih.gov/35656396/
